Mark has enjoyed a long relationship with English National Opera, and operatic engagements elsewhere include The Royal Opera House, Covent Garden, The Metropolitan Opera, New York, The Opéra National de Paris, The Netherlands Opera, La Monnaie, Welsh National Opera and Glyndebourne.  In 2017 he received the Oliver Award for Outstanding Achievement in Opera.

On the concert platform, highlights include performances with the Berlin Philharmonic, Royal Concertgebouw, Czech Philharmonic, London Symphony, London Philharmonic, Boston Symphony, New York Philharmonic, Philadelphia Orchestra, Chicago Symphony, Los Angeles Philharmonic, Cleveland Orchestra, Tokyo Symphony, and the Sydney Symphony.

His recordings include a critically acclaimed complete cycle of the Shostakovich Symphonies with the BBC National Orchestra of Wales and the Netherlands Radio Philharmonic, Mahler’s Sixth and Tenth symphonies, with the Melbourne Symphony, Britten’s Peter Grimes with Glyndebourne, and the Brahms Piano Concertos with Stephen Hough.

He has written articles for The Guardian and The Independent, made a six-part TV series for the BBC entitled Everything to Play For, and held positions as Associate Conductor of the BBC Symphony, Principal Guest Conductor of the Swedish Radio Symphony, and the Adelaide Symphony, Music Director of the BBC National Orchestra of Wales, and most recently Music Director of English National Opera.